Photoinduced Electron Transfer Fluorescent Primer for Nucleic Acid Amplification
CDC scientists have developed a rapid and cost-efficient method for generating fluorescently labeled primers for PCR and real-time PCR. At present, fluorescent primers are useful for detecting and...
View ArticleFluorescent Primer(s) Creation for Nucleic Acid Detection and Amplification
CDC researchers have developed technology that consists of a simple and inexpensive technique for creating fluorescent labeled primers for nucleic acid amplification. Fluorescent chemical-labeled...
View ArticleReal-Time RT-PCR Detection of Scrub Typhus Total Nucleic Acid Assay with High...
Scrub typhus is a bacterial disease caused by Orientia tsutsugamushi (O. tsutsugamushi or Ots) that is spread to people through bites of infected chiggers (larval mites). The most common symptoms can...
View ArticleReal-Time RT-PCR Detection of Rickettsia species -- PanR6/Total Nucleic Acid...
Rickettsial infections are caused by bacteria from the Rickettsia genus which are often spread by biting ticks, fleas, mites or lice. Rickettsia can cause mild to severe illness and Rickettsia species...
View ArticleUniversal Influenza Virus Probes for Enrichment of Influenza Viral Sequences
This technology is a set of influenza virus enrichment probes developed to increase the sensitivity of sequence-based, universal detection of all influenza viruses. This universal influenza enrichment...
View ArticleNovel One-Well Limiting-Antigen Avidity Enzyme Immunoassay to Detect Recent...
This CDC developed Limiting-Antigen avidity Enzyme Immunoassay (LAg-avidity-EIA) provides an easy way to measure increasing binding strength (avidity) of HIV antibodies as part of maturation HIV...
View ArticleSimian T-Cell Lymphotropic Virus Strain Type 3 (STLV-3) Subtype D Variant, a...
Simian T-cell lymphotropic viruses (STLV) are nonhuman primate retroviruses closely related to the human T-lymphotropic virus (HTLV). Types I, II, and III of HTLV have been found in humans and are...
View ArticleHigh-Throughput COVID-19 Diagnostic Test that Detects Both Viral and Host...
The rapid worldwide spread and impact of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a need for accurate, reliable, and readily accessible testing on a...
View ArticleMonoclonal Antibodies Against Coxiella burnetii, the Cause of Q Fever for...
Coxiella burnetii (C. burnetii), the bacterium that causes Q fever, gets transmitted by inhalation and remains extremely stable in the environment. It has a very low infectious dose (very few bacteria...
View ArticleStable Human Cell Lines Expressing Flavivirus Virus-Like Particles (VLPs) for...
Flaviviruses such as Zika virus, dengue virus, West Nile virus, yellow fever virus, and Japanese encephalitis virus cause widespread illness and death throughout the world. Typically, flaviviruses get...
View ArticleReducing Bloodstream Neutrophils as a Treatment for Lung Infection and...
During lung infection, bloodstream neutrophils (PMNs) responding to infection travel to the airspace lumen. Although successful arrival of microbicidal PMNs to the airspace is essential for host...
View ArticleMonoclonal Antibodies for Detection of Rabies Virus Antigen and Confirmatory...
According to the World Health Organization (WHO), rabies causes greater than 59,000 deaths every year in over 150 countries as of 2017. A rapid and reliable diagnostic test for rabies is critical for...
View ArticleMonoclonal Antibody that Detects a Subclass of Dog IgG—for Diagnostic and...
CDC and collaborating researchers have developed a new monoclonal antibody that recognizes canine IgG (likely IgG4 subclass). This anti-dog IgG reagent could be used to detect antibody reactions to a...
View ArticleDiagnostic Assay to Detect Group C Rotavirus in Humans and Animals—Monoclonal...
Rotaviruses cause severe gastroenteritis in humans and animals globally. Currently, there are eight known serogroups (A-H) of rotaviruses. Group C rotavirus (GpC RV) causes sporadic cases and outbreaks...
View ArticleHybridomas to Human Immunoglobulins for SARS-CoV-2 Diagnostics and Additional...
Immunoglobulins play a key role in the immune system. CDC has developed and tested hybridoma cell lines (monoclonal antibody (mAb) clones) for human IgG and other immunoglobulins. The mAbs generated...
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